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Thermo Fisher
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Thermo Fisher
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Abbkine Inc
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FUJIFILM
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Millipore
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Fisher Scientific
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Thermo Fisher
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Fluka Chemical
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Image Search Results
Journal: Respiratory Research
Article Title: SARS coronavirus 2: from genome to infectome
doi: 10.1186/s12931-020-01581-z
Figure Lengend Snippet: The transmission cycle of SARS-CoV-2. The SARS-CoV-2 originated from bats and pangolins are presumed to be their intermediate amplifying hosts. The virus transmits from animal-to-human to human-to-human. The infected person transmits the virus through cough and sneeze. In the population, there are asymptomatic carrier which spread the virus without any signs or symptoms
Article Snippet: 14. ,
Techniques: Transmission Assay, Infection
Journal: Respiratory Research
Article Title: SARS coronavirus 2: from genome to infectome
doi: 10.1186/s12931-020-01581-z
Figure Lengend Snippet: Schematic presentation of the SARS-CoV-2 genome Structure. SARS-CoV-2 has a spherical structure. The virus has an outer lipid envelope, covered with spike glycoprotein. The SARS-CoV-2 represents a typical Betacoronavirus genome organisation. The full-length RNA genome comprises of approximately 29,903 nucleotides and has a replicase complex (comprised of ORF1a and ORF1b) at the 5′UTR. The ORF1a encodes for nsp1–nsp10, while ORF1b encodes for nsp1–nsp16. Four genes that encode for the Structural proteins: Spike gene, Envelope gene, Membrane gene, Nucleocapsid gene and a poly (A) tail at the 3′UTR. The accessory genes are distributed in between the structural genes
Article Snippet: 14. ,
Techniques:
Journal: Respiratory Research
Article Title: SARS coronavirus 2: from genome to infectome
doi: 10.1186/s12931-020-01581-z
Figure Lengend Snippet: The SARS-CoV-2 replication and pathogenesis. a The SARS-CoV-2 infects upper and lower respiratory tract. b The virus replication from 1 to 12 has been described as, (1) The virus identifies the ACE-2 receptor. (2) The binding is initiated by the Spike (S) glycoprotein of SARS-CoV-2 by receptor binding domain (RBD) to the ACE-2 receptor binding motif (RBM). (3, 4) The virus-receptor internalization occurs and a membrane fusion is carried out by S2 subunit of S glycoprotein followed by the uncoating of +ssRNA inside cytoplasm. (5–7) The +ssRNA directly translate into non-structural proteins for initiating the viral replication through RNA-dependent RNA polymerase (RdRp/nsp12) and forms -ssRNA which act as template for synthesizing various copies of +ssRNA. (8–10) The +ssRNA along with the structural protein are trafficked to ER-Golgi complex for assembly and maturation. (11–12) The vesicles-encapsulated virion fuses with the cell membrane and through exocytosis release outside the cell to infect nearby cell. The immune response: the cellular RNA receptors like, RIG-I and MDA-5 recognized the dsRNAs in cytoplasm, activating the pro-inflammatory response and antiviral response inside cells. The cytokines activate the macrophages and lymphocytes to kick start both cellular and humoral response. c The virus disseminates to the other part of body through blood affecting the brain, heart, liver spleen, large intestine, kidneys
Article Snippet: 14. ,
Techniques: Binding Assay
Journal: Respiratory Research
Article Title: SARS coronavirus 2: from genome to infectome
doi: 10.1186/s12931-020-01581-z
Figure Lengend Snippet: Diagnostic kits for COVID-19
Article Snippet: 14. ,
Techniques: Diagnostic Assay, Quantitative RT-PCR
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Journal: Respiratory Research
Article Title: SARS coronavirus 2: from genome to infectome
doi: 10.1186/s12931-020-01581-z
Figure Lengend Snippet: List of candidate vaccines against COVID-19. This table has been taken with permission from the WHO website (Draft landscape of COVID19 candidate vaccine) with slight modifications [
Article Snippet: 14. ,
Techniques: Plasmid Preparation, Recombinant, Electroporation, Produced, Derivative Assay